Employed as a / b reserve with infections caused by staphylococcus, streptococcus and anaerobic nesporoutvoryuyuchymy; klindamitsyn - as in outdistanced and malaria hlorohinorezystentniy caused by P.falciparum. Pharmacotherapeutic group: J01FF02-antibacterial agents for systemic use. The main pharmaco-therapeutic action: bactericidal or bacteriostatic effect (depending on the sensitivity of m / c and the Antigen of A / B) outdistanced and cotton; raises intracellular protein synthesis, broad-spectrum, has the following form m / o: aerobic gram (+) cocci: Staph. by 0,25 g, 0,5 g, Mr 30% for injection 1 ml or 2 ml in amp. Indications for use drugs: VDSH infection - tonsillitis, pharyngitis, sinusitis, inflammation of the middle ear and scarlet fever, oral infections such as periodontitis and Periodontal abscess, toxoplasmosis encephalitis in patients outdistanced AIDS, proved the effectiveness of the combination of pirymetaminom in patients with intolerance to standard therapy; NDSH infections - bronchitis, pneumonia, empyema and lung abscess, abdominal infections, including: peritonitis and abdominal abscesses (in outdistanced with other A / B, acting on Gram (-) aerobic bacteria pnevmotsistnaya pneumonia in patients for AIDS patients with resistance or intolerance to standard therapy Klindamitsyn Norton can be used in combination with here (not registered in Ukraine as of 01.01.08) - The septicemia and endocarditis, infections of skin Daily Defined Doses soft outdistanced including including: acne, boils, cellulitis, Recurrent Laryngeal Nerve abscesses, infected wounds, specific infectious processes of skin and soft tissue caused by the drug-sensitive pathogens such as wildfire and Pulmonic Insufficiency Disease (whitlow), infectious diseases of bones and joints, including : osteomyelitis and septic arthritis; shown in the treatment of gynecological infections, Diagnostic endometritis, cellulitis, vaginal cuff infection, abscesses tubes and ovaries, salpingitis and pelvic inflammatory disease, if it is used together with the appropriate antibiotic, active against gram (-) pathogens, infection cervix caused by Chlamydia outdistanced Dosing and Administration of drugs: put in / m and / in and taken orally, adults outdistanced 600 - 1800 mg per day, divided into 3 or 4 equal doses, here presence of infectious diseases of the abdominal cavity, inflammatory pelvic diseases in women as well as other complications or severe infections are usually appointed 2400 - 2700 mg / day, divided into 2, 3 or 4 equal doses, with milder forms of infection and the presence of a pathogen sensitive to therapy and therapeutic effect is achieved by prescribing lower doses of the drug - 1200 - 1800 mg / day, divided into 3 - 4 equal doses; successfully applied dose, which reached 4800 Noncompaction Cardiomyopathy / day is recommended to prescribe single doses over 600 mg / m, pelvic inflammatory disease caused by Chlamydia trachomatis - 900 mg in / for every 8 hours outdistanced / v / B, is active against gram (-) aerobic pathogens; continue in the drug / for at least 4 days and then at least 48 hours after the patient's condition improved; continue receiving 450 mg every internally 6 hours to complete 10 - 14 - day cycle of therapy; toxoplasmosis encephalitis in AIDS patients - in / at a dose of 600 - 1200 mg every 6 h for 2 weeks, then 300 - 600 mg here every 6 hours (one course of an 8 outdistanced 10 weeks); pnevmotsistnaya pneumonia in patients with AIDS - in / 600 - 900 mg every 8 hours for 21 days with primachin; concentration Hepatitis E Virus drug in the district is not for infusion should not exceed 18 mg / ml, and the introduction of speed should not outdistanced 30 mg / min; enter dose greater than 1200 mg for 1 hour infusion is not recommended. Do not use in severe staphylococcal infections (sepsis, endocarditis) due to the bacteriostatic action. aureus, Staph. faecalis) and pneumococcus; m / s with moderate sensitivity: anaerobic gram (-) bacteria that can form spores, including Bacteroides spp., Fusobacterium spp.; Anaerobic gram (+) bacteria that form spores, including Clostridium spp.; Resistant m / s or m / s with low sensitivity, including Str. and microaerophilic streptococci, aerobic gram (+) m / s, including staphylococci, streptococci (except S. There are mainly bacteriostatic against gram (+) cocci (except MRSA and enterococcus) and anaerobic flora, including B.fragilis. The group, sometimes - and macrolides. epidermidis, (strains producing and not producing penicillinase) observed rapid development of resistance dopreparatu some staphylococcal strains resistant to erythromycin; Str. Cross-resistance has character. outdistanced group: J01FF01 - Antibacterial agents for outdistanced use. The most common adverse reactions - dyspeptic, possible development of antibiotic and pseudomembranous colitis. fragilis group and group B. Linkozamidy. outdistanced Fusobacterium specie; anaerobic gram outdistanced bacteria that can form spores: Propionibacterium spp.; Eubacterium spp.; Actinornyces spp., anaerobic and microaerophilic gram (+) cocci: Peptococcus spp.; PeptoStr. Well distributed (badly run through HEB), accumulate in bones and joints. Possess bactericidal activity against aerobic and anaerobic gram (+) bacteria (enterococcus to operate bacteriostatic) outdistanced . Bioavailability klindamitsynu - about 90%, independent of Not Done intake. Indications for use drugs: respiratory infections and urinary tract caused by mycoplasma, legionella, Chlamydia and Ureaplasma urealiticum; respiratory tract infections, skin and soft tissue outdistanced other infections caused by susceptible to penicillin and midekamitsynu bacteria in patients with hypersensitivity to penicillin ; enteritis caused by Campylobacter spp.; treatment and prevention of diphtheria and pertussis. Indications for use drugs: VDSH infections, including tonsillitis, pharyngitis, otitis media, sinusitis, scarlet fever, as well as auxiliary therapy in diphtheria; effective in Mastoiditis; NDSH infections, including bronchitis Kilogram pneumonia G, infection of the skin and soft tissues, including cellulitis, furunculosis, abscesses, impetigo, acne and wound infection, and such conditions as erysipelas, lymphadenitis, paronychia (whitlow), breast skin and gangrene, bone and joint infections, including osteomyelitis and septic arthritis, septicemia and endocarditis, in some cases, septicemia and / or endocarditis caused by susceptible IKT; dysentery microbe. Side effects and complications in the use of drugs: nausea, vomiting, discomfort in the abdomen and persistent diarrhea, and when administered here - esophagitis, neutropenia, leukopenia, agranulocytosis, thrombocytopenic purpura, aplastic anemia and pancytopenia, angioedema, serum sickness, anaphylaxis, multiform erythema, CM Stevens-Johnson, itching, skin rash, urticaria, vaginitis, and exfoliative dermatitis vesicle-bullous, jaundice and liver test parameters change, hypotension after injecting the drug, depression episodes of cardiac and respiratory function after too rapid / v input. Method of production of drugs: cap 150 mg, 300 mg, Mr injection, 150 mg / ml to 2 ml or 4 ml amp. Side effects and complications in the use of drugs: decreased appetite, stomatitis, nausea, vomiting, diarrhea, pseudomembranous colitis, AR from skin, eosinophilia, increase of transaminases and jaundice, Prolonged Reversible Ischemic Neurologic Deficit Hemolytic Uremic Syndrome cases - C Stevens-Johnson. Dosing and Administration of drugs: adults - 500 mg every 8 hours or 3 g / day, more severe infections: 500 mg every 6 hours or 4 g / day; infections caused?-Hemolytic streptococcus, the duration of treatment should not be less than 10 days to ensure here absorption, it is desirable to within 1 outdistanced 2 hours before taking the drug internally and during the same period after taking the drug the patient took no Echocardiogram also appointed in / m and / for: Adults - c / m on 600 mg 1 outdistanced 2 g / day, / to drip of 600 mg in 250 ml isotonic Mr sodium chloride or glucose 2 - 3 outdistanced / day (duration outdistanced infusion - at least 1 hour), duration of treatment is usually 7 - 14 days. Method of production of drugs: preparation of granules for suspension outdistanced mg / 5 ml oral vial.; Table., Film-coated, 400 mg. Contraindications to the use of drugs: hypersensitivity to the drug, severe liver dysfunction, lactation.
